Progress in defining the genetic contribution to type 2 diabetes susceptibility
نویسندگان
چکیده
منابع مشابه
Genetic susceptibility to type 2 diabetes and implications for therapy.
Since 2000, we have witnessed an explosion of known genetic determinants of type 2 diabetes risk. These findings have seeded the expectation that our ability to make personalized, predictive, therapeutic clinical decisions is imminent. However, the loci discovered to date explain only a small fraction of overall inheritable risk for this disease. In many cases, the reported associations merely ...
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Diabetes mellitus is a chronic condition characterized by increased glucose level due to absence/insufficient insulin secretion (Figure 1). The old classification of diabetes divided it into juvenileand maturity-onset diabetes. Now an etiology based classification devised by the American Diabetes Association (ADA) and the World Health Organization (WHO) is used that divides diabetes into: type ...
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We have carried out a detailed reexamination of the genetics of the APM1 locus and its contribution to the genetic basis of type 2 diabetes susceptibility in the French Caucasian population. The G allele of single nucleotide polymorphism -11426 in the APM1 promoter showed modest association with type 2 diabetes (odds ratio 1.44 [95% CI 1.04-1.98]; P = 0.03), providing corroborative evidence tha...
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Background: Type 2 diabetes Mellitus (T2DM) is a multifactorial, polygenic disease caused by impaired insulin secretion, insulin resistance and beta-cell dysfunction. Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. Melatonin and the genetic variants of MTNR1B gene are reported to be associated with T2DM susceptibility. We ...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2018
ISSN: 0959-437X
DOI: 10.1016/j.gde.2018.02.003